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The Mouse Genome Database (MGD): the model organism database for the laboratory mouse
Judith A Blake1, Joel E Richardson, Carol J Bult
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. jblake@informatics.jax.org
Nucleic Acids Research
|December 26, 2001
Summary
The Mouse Genome Database (MGD) is a vital resource for mouse genetics research, offering curated data on genes, alleles, and phenotypes. It enhances understanding of human biology and disease through comparative genomics with human and rat genomes.
Area of Science:
- Genomics
- Bioinformatics
- Comparative Genomics
Background:
- The laboratory mouse is a crucial model organism for human biology and disease research.
- Access to curated, integrated genomic data is essential for advancing biological understanding.
Purpose of the Study:
- To describe the Mouse Genome Database (MGD) as a comprehensive resource for mouse genetics.
- To highlight MGD's role in comparative genomics, particularly with human and rat genomes.
- To detail recent updates and integrations within the MGD.
Main Methods:
- Data curation and integration from various sources.
- Inclusion of experimental data, evidence, and citations for gene attributes.
- Detailed descriptions of alleles, genotypes, molecular variants, and phenotypes.
- Collaboration with data providers like NCBI, RIKEN, and SWISS-PROT for standardization.
Main Results:
- MGD provides a consensus view of current mouse knowledge.
- Comparative genomic information for human and rat genomes is integrated.
- Extensive gene, allele, and mutant data are available, linked to evidence.
- Recent integration of mouse full-length cDNAs and ESTs.
Conclusions:
- MGD serves as a key community resource for mouse genetics.
- The database facilitates the interpretation of the human genome and disease research.
- Ongoing developments enhance MGD's utility for biological and biomedical research.