Related Experiment Videos
Rat Genome Database (RGD): mapping disease onto the genome
Simon Twigger1, Jian Lu, Mary Shimoyama
1Bioinformatics Research Center and Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Nucleic Acids Research
|December 26, 2001
Summary
The Rat Genome Database (RGD) consolidates rat genetic and genomic data, aiding research into human diseases. It offers tools for comparative genomics and community outreach, enhancing its value for diverse scientific studies.
Area of Science:
- Genomics
- Bioinformatics
- Comparative Genomics
Background:
- The Rat Genome Database (RGD) is an NIH-funded initiative.
- RGD aims to centralize and disseminate rat genetic and genomic research data.
- Rats serve as a crucial model for human disease research.
Purpose of the Study:
- To create a comprehensive resource for rat genetic and genomic data.
- To support researchers studying the rat and its relevance to human health.
- To facilitate comparative genomics across rat, mouse, and human.
Main Methods:
- Integration of curated data on rat genes, QTL, microsatellite markers, and strains.
- Development of VCMap, a sequence-based homology tool for cross-species gene mapping.
- Ongoing literature and bulk dataset curation for continuous expansion.
Main Results:
- RGD version 2.0 includes extensive curated genetic and genomic information.
- VCMap enables visualization of mapped genes and sequences across species.
- RGD provides tools for gene prediction, radiation hybrid mapping, and marker selection.
Conclusions:
- RGD is a valuable, expanding resource for rat research and comparative genomics.
- Future developments include disease-specific curation and integration with genomic sequences.
- RGD supports the scientific community through data sharing and outreach programs like the Rat Community Forum.