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Genew: the human gene nomenclature database.

Hester M Wain1, Michael Lush, Fabrice Ducluzeau

  • 1HUGO Gene Nomenclature Committee (HGNC), Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK. nome@galton.ucl.ac.uk

Nucleic Acids Research
|December 26, 2001
PubMed
Summary

The Human Gene Nomenclature Database (HGNC) provides curated data for all approved human gene symbols. This resource facilitates gene symbol and name searches, integrating with other databases for comprehensive human gene information.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Human Genetics

Background:

  • The Human Gene Nomenclature Database (Genew) is the sole repository for all human genes with approved symbols.
  • Managed by the HUGO Gene Nomenclature Committee (HGNC), it contains over 16,000 curated records.

Purpose of the Study:

  • To describe the Genew database and its functionalities for accessing human gene nomenclature data.
  • To highlight the curation process and data integration with other biological databases.

Main Methods:

  • Data curation by HGNC editors.
  • Web-based search functionality for gene symbol and name retrieval.
  • Integration with external databases like GDB, LocusLink, and SWISS-PROT.
  • Coordination with the Mouse Genome Database (MGD) for gene symbol consistency.

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Main Results:

  • Genew provides access to over 16,000 human gene records.
  • 80% of the database is accessible via searchable text files on the web.
  • Users can retrieve gene symbol, name, cytogenetic location, OMIM, and PubMed IDs.
  • Approved gene symbols are harmonized with the Mouse Genome Database.

Conclusions:

  • Genew serves as a critical, highly curated resource for human gene nomenclature.
  • The database enables efficient retrieval and integration of essential human gene information.
  • Web accessibility and data integration enhance its utility for researchers worldwide.