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Related Experiment Videos

Recent improvements to the SMART domain-based sequence annotation resource.

Ivica Letunic1, Leo Goodstadt, Nicholas J Dickens

  • 1EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany.

Nucleic Acids Research
|December 26, 2001
PubMed
Summary
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The Simple Modular Architecture Research Tool (SMART) annotates protein domains and analyzes domain architectures. The latest release enhances this resource with over 600 domain families and improved analysis methods.

Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Computational Biology

Background:

  • Protein domain annotation and analysis are crucial for understanding protein function and evolution.
  • Mobile eukaryotic domains play significant roles in cellular processes.
  • Existing tools may lack comprehensive annotation or advanced analysis capabilities.

Purpose of the Study:

  • To present the updated Simple Modular Architecture Research Tool (SMART) resource.
  • To highlight new features and expanded content in the January 2002 release.
  • To facilitate the analysis of protein domain architectures, particularly for eukaryotic mobile domains.

Main Methods:

  • Web-based resource for protein domain annotation and architecture analysis.
  • Inclusion of over 600 hand-curated domain families with detailed functional and structural information.

Related Experiment Videos

  • Integration of links to the Online Mendelian Inheritance in Man (OMIM) database for disease-associated domains.
  • Implementation of new and updated analysis methods, including advanced SQL queries for direct database access.
  • Inclusion of intrinsic sequence features like transmembrane regions and signal peptides in the database.

    • Main Results:

    • The SMART resource now encompasses over 600 domain families, with more than 200 added in the latest release.
    • Annotation includes comprehensive data on function, localization, distribution, and structure.
    • New features enable direct querying of intrinsic sequence features and links to disease-related information.
    • A mirror site has been established to improve accessibility.

    Conclusions:

    • SMART is a valuable and expanding resource for protein domain analysis.
    • The updated version provides enhanced capabilities for researchers studying protein architecture and function.
    • The integration of disease-related information and advanced querying tools increases the utility of SMART for biological research.