Related Experiment Video
Updated: Jul 14, 2026
08:50
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Acetaminophen, aspirin, and chronic renal failure
C M Fored1, E Ejerblad, P Lindblad
1Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden. michael.fored@mep.ki.se
The New England Journal of Medicine
|December 26, 2001
Summary
Regular use of aspirin or acetaminophen significantly increases the risk of chronic renal failure. This association was observed across various renal conditions, highlighting potential kidney damage from common pain relievers.
Area of Science:
- Nephrology
- Epidemiology
- Pharmacology
Background:
- Epidemiologic studies suggest a link between heavy nonnarcotic analgesic use and chronic renal failure.
- The causal relationship between analgesic consumption and kidney disease remains unclear.
Purpose of the Study:
- To investigate the association between analgesic use and the risk of developing chronic renal failure.
- To estimate relative risks for disease-specific chronic renal failure linked to various analgesics.
Main Methods:
- A nationwide, population-based, case-control study in Sweden.
- Face-to-face interviews with 926 newly diagnosed chronic renal failure patients and 998 controls.
- Logistic-regression models to assess analgesic use and renal failure risk.
Main Results:
- Regular aspirin and acetaminophen use was more frequent in renal failure patients (37% and 25%) than controls (19% and 12%).
- Regular use of either drug independently increased chronic renal failure risk by 2.5 times.
- Increased risks were dose-dependent and more pronounced with acetaminophen, affecting most renal disease types.
Conclusions:
- Findings support the hypothesis that acetaminophen and aspirin can exacerbate chronic renal failure.
- Potential bias from predisposing conditions triggering analgesic use cannot be excluded.
More Related Videos
Related Concept Videos
01:17Factors Affecting Renal Clearance: Renal Impairment
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
01:11Renal Failure: Dose Adjustments
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
01:25Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
In patients with renal disease, dosage adjustments are necessary to maintain therapeutic plasma drug concentrations and prevent toxicity or subtherapeutic exposure. Renal impairment alters drug pharmacokinetics, especially in conditions like uremia, where changes such as prolonged elimination half-life and altered apparent volume of distribution can significantly affect drug disposition. These changes require careful modification of the dosing regimen to achieve the desired clinical...
01:30Drug toxicity: Drug–Drug Interaction
Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:28Chronic Kidney Disease III: Interprofessional Care
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...