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Updated: Jul 17, 2026

Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy
Published on: October 20, 2014
Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway
J Whistler1, E Beattie, M von Zastrow
1Department of Neurology, University of California, San Francisco, CA 94143-0984, USA.
Abstract:
In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.
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