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Coregulation of ion channels by neurosteroids and phosphorylation
1Department of Cell and Molecular Biology, Tulane University, New Orleans, LA, USA. tasker@tulane.edu
Science'S STKE : Signal Transduction Knowledge Environment
|December 26, 2001
Abstract:
This Perspective by Tasker is one of two discussing the regulation of ion channels by neurosteroids. Neurosteroids are steroids synthesized in the brain that act as allosteric modulators of ion-channel activity. The dual regulation of gamma-aminobutyric acid type A (GABA(A)) receptors and voltage-gated calcium channels by phosphorylation and neurosteroids is the focus of this Perspective.