Related Experiment Video
Updated: Aug 12, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Dueling enigmas: neurosteroids and sigma receptors in the limelight
1Laboratory of Molecular Neurobiology, Department of Pharmacology, Boston University School of Medicine, Boston, MA, USA. tgibbs@bu.edu
Abstract:
Neurosteroids can be positive or negative regulators of neurotransmitter receptor action, depending on the receptor and the chemical structure of the neurosteroid. This Perspective by Gibbs and Farb is one of two on the subject of neurosteroids. The authors address the possible role of sigma receptors in mediating neurosteroid action and describe how the regulation of inhibitory and excitatory ion channels by neurosteroids has implications for the role of these molecules in learning and memory, nociception, and excitotoxicity.
More Related Videos
Related Concept Videos
Regulation of Nuclear Protein Sorting
Transducer Mechanism: Nuclear Receptors
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
The Two-State Receptor Model
The binding affinity of a drug determines its interaction with one...
Neurochemical Transmission: Sites of Drug Action
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
Opioid Receptors: Overview

