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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener

W E Miller1, R J Lefkowitz

  • 1Howard Hughes Medical Institute, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. millerw@receptor-biol.duke.edu

Science'S STKE : Signal Transduction Knowledge Environment
|December 26, 2001
PubMed

Insights

Internalized receptor-arrestin complexes actively signal, potentially inducing apoptosis. This occurs independently of G protein activation, revealing new cellular communication pathways.

Area of Science:

  • Cellular signaling
  • Molecular biology
  • Apoptosis

Background:

  • Recent data indicate internalized receptor and arrestin complexes play active roles in signal transduction.
  • The precise functions of these intracellular complexes are under investigation.

Purpose of the Study:

  • To explore the role of intracellular receptor-arrestin complexes in cellular signaling.
  • To investigate the potential involvement of these complexes in apoptosis and proliferation.

Main Methods:

  • Review of evidence from the Drosophila visual system.
  • Analysis of experiments with activated mammalian G protein-coupled receptor and arrestin complexes.

Main Results:

  • Evidence suggests intracellular rhodopsin and arrestin2 complexes in Drosophila can induce apoptosis.
  • Activated mammalian G protein-coupled receptor and arrestin complexes mediate signals independent of G protein activation.

Conclusions:

  • Internalized receptor-arrestin complexes are actively involved in signal transduction.
  • These complexes can mediate proliferative or proapoptotic signals independently of canonical G protein pathways.

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