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CD14 and LBP in endotoxemia and infections caused by Gram-negative bacteria

D Heumann1

  • 1Division of Infectious Diseases, CHUV, Lausanne, Switzerland. dheumann@hola.hospvd.ch

Journal of Endotoxin Research
|December 26, 2001
PubMed

Insights

Plasma lipopolysaccharide-binding protein (LBP) and CD14 are key innate immune molecules. This review examines their roles in endotoxemia and infection models.

Area of Science:

  • Immunology
  • Microbiology

Background:

  • Plasma lipopolysaccharide-binding protein (LBP) and membrane CD14 are crucial for innate immunity.
  • These molecules are involved in the response to lipopolysaccharide (LPS) and other bacterial products.

Purpose of the Study:

  • To review the roles of LBP and CD14.
  • To explore their functions in models of endotoxemia and infection.

Main Methods:

  • Literature review of studies on LBP and CD14.
  • Analysis of findings from endotoxemia and infection models.

Main Results:

  • LBP and CD14 are central to the innate immune response.
  • Their involvement in endotoxemia and infection is significant.

Conclusions:

  • LBP and CD14 are critical components of the innate immune system.
  • Understanding their roles is vital for studying infectious diseases and sepsis.

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