Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CYP2D6 polymorphism in a Mexican American population.

R Mendoza1, Y J Wan, R E Poland

  • 1Department of Psychiatry, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

Clinical Pharmacology and Therapeutics
|December 26, 2001
PubMed
Summary

Mexican Americans show a lower frequency of the CYP2D6*4 allele compared to Caucasians. This genetic pattern may influence drug metabolism rates in this population.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Study on the hospitalization cost and its influencing factors of imported malaria patients in Guangxi Zhuang Autonomous Region and Yunnan Province].

Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control·2021
Same author

Effect of soil fortified by polyurethane foam on septic tank effluent treatment.

Water science and technology : a journal of the International Association on Water Pollution Research·2011
Same author

Association of tri-nucleotide (CAG and GGC) repeat polymorphism of androgen receptor gene in Taiwanese women with refractory or remission rheumatoid arthritis.

Clinical rheumatology·2007
Same author

Transcultural issues.

Handbook of experimental pharmacology·2006
Same author

Functional activity of three distinct myeloperoxidase (MPO) promoters in human myeloid cells.

Leukemia·2002
Same author

Culture and psychopharmacology.

The Psychiatric clinics of North America·2001

Area of Science:

  • Pharmacogenomics
  • Genetics
  • Population Studies

Background:

  • Limited pharmacogenetic data exists for Mexican Americans, a significant demographic group.
  • Understanding genetic variations in drug metabolism is crucial for personalized medicine.

Purpose of the Study:

  • To investigate the CYP2D6 genotype and dextromethorphan hydroxylation phenotype in Mexican Americans.
  • To establish baseline pharmacogenetic data for this underrepresented population.

Main Methods:

  • Genotyping for CYP2D6 alleles in 349 Mexican American subjects.
  • Phenotyping using dextromethorphan hydroxylation in 285 subjects.
  • Analysis of allelic frequencies and metabolizer status.

Main Results:

Related Experiment Videos

  • Identified specific allelic frequencies for CYP2D6 variants (e.g., CYP2D6*2, CYP2D6*4).
  • Observed a 3.2% incidence of poor metabolizers, lower than in some Caucasian populations.
  • Correlated the number of functional alleles with metabolic phenotype, indicating a gene-dose effect.

Conclusions:

  • Mexican Americans exhibit a lower frequency of the CYP2D6*4 allele compared to Caucasians.
  • Observed genotypic patterns may explain differences in poor metabolizer rates and enzyme activity.
  • This study provides essential pharmacogenetic insights for the Mexican American population.