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Eradication of a dysfunctional HLA-haploidentical T cell system by a second HLA-identical BMT

M Ege1, B J Manfras, G Barbi

  • 1Department of Paediatrics, University of Ulm, Ulm, Germany.

Bone Marrow Transplantation
|December 26, 2001
PubMed

A 12-year-old boy treated for SCID at 1 month of age by HLA-haploidentical BMT developed a lymphoproliferative disease of unknown etiology at the age of 9 years characterized by sustained, marked elevation of circulating CD8+ donor T cells and by diffuse infiltration of the liver by CD8+ T cells. Because of progressive liver disease, the patient underwent a second BMT from a younger HLA-matched sister. This treatment induced an effective graft-versus-graft reaction and led to complete replacement of the HLA-nonidentical, dysfunctional T cell system, resolution of the hepatopathy and full reconstitution of T and B cell functions.

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