Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrapleural tetracycline for malignant pleural effusions.

H W Wallach

    Chest
    |October 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Tetracycline instillation after pleural fluid drainage effectively prevented malignant pleural effusion recurrence in seven patients. This treatment showed promise despite some patients worsening on chemotherapy and eventually dying.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Treatment of thrombotic thrombocytopenic purpura with plasma infusions and cyclophosphamide.

    Southern medical journal·1979
    Same author

    Tamoxifen flare.

    JAMA·1979
    Same author

    Sciatic nerve compression during anticoagulation therapy. Computerized tomography aids in diagnosis.

    Archives of neurology·1979
    Same author

    Intrapleural therapy with tetracycline and lidocaine for malignant pleural effusions.

    Chest·1978
    Same author

    Lupus-like syndrome associated with carcinoma of the breast.

    Archives of internal medicine·1977
    Same author

    Medroxyprogesterone acetate (Provera R ) therapy in acromegaly associated with heart disease.

    The Medical annals of the District of Columbia·1973

    Area of Science:

    • Pulmonology
    • Oncology
    • Thoracic Surgery

    Background:

    • Malignant pleural effusions are a common complication of various cancers.
    • Recurrent effusions can cause significant symptoms and impact quality of life.
    • Effective management strategies for malignant pleural effusions are crucial.

    Purpose of the Study:

    • To evaluate the efficacy of tetracycline instillation as a pleurodesis agent for malignant pleural effusions.

    Main Methods:

    • Seven patients with malignant pleural effusions underwent closed-tube thoracostomy for drainage.
    • Tetracycline was instilled into the pleural space post-drainage.

    Main Results:

    • No clinically significant recurrence of pleural effusion was observed in any of the seven patients.

    Related Experiment Videos

  • Four patients experienced disease progression during systemic chemotherapy and subsequently died.

    • Conclusions:

    • Tetracycline instillation following closed-tube thoracostomy appears to be an effective method for preventing malignant pleural effusion recurrence.
    • Further studies are warranted to confirm these findings in a larger cohort.