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New sesquiterpene derivatives from the red alga Laurencia scoparia. Isolation, structure determination, and
D Davyt1, R Fernandez, L Suescun
1Cátedra de Química Farmacéutica, Facultad de Química, Universidad de la República, Avenida Gral. Flores 2124, Montevideo, Uruguay.
Abstract:
Eleven sesquiterpenes (1-11) and one long chain aldehyde (12) have been isolated from the dichloromethane extract of the red alga Laurencia scoparia. Four of them are new natural products. Scopariol (1) is a new natural product with an unusual rearranged chamigrane-type structure. The other three are beta-chamigrenes: isorigidol (2), (+)-3-(Z)-bromomethylidene-10 beta-bromo-beta-chamigrene (3), and (-)-3-(E)-bromomethylidene-10 beta-bromo-beta-chamigrene (4). The in vitro activity of compounds 1-12 against the parasitant stage of Nippostrongylus brasiliensis (L4) has been studied.
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