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Lecithin: cholesterol acyltransferase is insufficient to prevent oxidative modification of low-density lipoprotein
Youhei Murakami1, Shin Kamiyama, Zakir H Howlader
1Laboratory of Nutrition, Graduate School of Agricultural Science, and Gene Research Center, Tohoku University, Tsutsumidori, Amamiya-machi, Aoba-ku, Sendai 981-8555, Japan.
Journal of Biochemistry
|January 5, 2002
Abstract:
We tried to confirm the antioxidative capability of lecithin:cholesterol acyltransferase (LCAT) reported by Vohl et al. [Biochemistry (1999) 38, 5976-5981]. The enzyme solution protected LDL against oxidation. However, this protection was not due to LCAT enzyme, but to some unknown low-molecular-weight substance(s) in the solution; LCAT itself exerted little protective effect against LDL oxidation.