[Fibrinolytic treatment for patients with prosthesis thrombosis and high surgical risk]

We retrospectively analyzed the response to fibrinolytic treatment in a group of 5 patients with prosthetic thrombosis, one of whom was a pregnant woman. All the patients were in functional class IV (NYHA), and the risk of surgery was considered very high for the following reasons: cardiogenic shock in 2 cases, severe depression of ventricular function in 1 case, and 3 and 4 prior interventions in 2 patients. The treatment was effective in 4 cases and the fifth patient died in cardiogenic shock. There were no major hemorrhagic complications and one case of peripheral embolism was detected. The treatment was effective and no obstetric or fetal complications were observed in the pregnant woman. We believe that fibrinolytic treatment is a good alternative for patients with prosthetic thrombosis and very high surgical risk and it may even be effective during pregnancy.