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Zinc and perinatal growth.
E Doménech1, N M Díaz-Gómez, F Barroso
1Department of Paediatrics. University Hospital of the Canaries, Faculty of Medicine, University of La Laguna, 38320, Santa Cruz de Tenerife, La Laguna, Spain. edomenec@ull.es
Early Human Development
|January 5, 2002
Summary
Perinatal nutrition impacts insulin-like growth factor-I (IGF-I) levels. Zinc and osteocalcin levels were lower in small for gestational age (SGA) infants during early postnatal life, indicating nutritional influences on growth and bone turnover.
Area of Science:
- Neonatal nutrition and growth
- Endocrinology and metabolism
- Pediatric bone health
Background:
- Perinatal growth is influenced by nutritional status.
- Insulin-like growth factor-I (IGF-I), osteocalcin, and zinc are key markers of growth and bone metabolism.
- Understanding these relationships is crucial for optimizing infant development.
Purpose of the Study:
- To investigate the interrelation between zinc, IGF-I, osteocalcin, and perinatal growth.
- To compare these markers in preterm appropriate for gestational age (AGA), full-term SGA, and full-term AGA newborns.
Main Methods:
- Measurements of anthropometric variables, serum IGF-I, osteocalcin, and zinc.
- Study included preterm AGA, full-term SGA, and full-term AGA neonates.
- Data collected at birth, 1 week, and 3 weeks postpartum.
Main Results:
- Full-term SGA infants exhibited lower IGF-I at birth.
- Subcutaneous fat was reduced in full-term SGA and preterm AGA infants at 1 week.
- Full-term SGA infants showed lower osteocalcin and zinc levels at 1 week, with zinc remaining low at 3 weeks.
Conclusions:
- Perinatal nutrition significantly affects IGF-I levels.
- Low osteocalcin in SGA infants suggests reduced bone turnover.
- Serum zinc levels progressively decrease postnatally, particularly in full-term SGA infants.