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DNA cleavage by pentadentate iron(II) complexes containing fluoro-substituted phenyl groups
Hiromasa Kurosaki1, Aoi Maruyama, Hiroyuki Koike
1Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
Bioorganic & Medicinal Chemistry Letters
|January 5, 2002
Abstract:
Four pentadentate iron(II) complexes containing non- or fluoro-substituted phenyl group (2b-2e) were synthesized and cleaving activity of them to pUC19 DNA was evaluated in the presence of hydrogen peroxide. DNA cleavage activity increased with the number of substituted fluorine atoms on the phenyl group of 2b.