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Detection of p53 gene mutations by single strand conformational polymorphism (SSCP) in human acute myeloid

Diana S Fleckenstein1, Cord C Uphoff, Hans G Drexler

  • 1Department of Human and Animal Cell Cultures, DSMZ-German Collection of Microorganisms and Cell Cultures, Mascheroder Weg 1 B, D-38124 Braunschweig, Germany.

Leukemia Research
|January 5, 2002
PubMed

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...