Bilateral endogenous endophthalmitis caused by HACEK microorganism
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Updated: Oct 3, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Preston Sullivan1, William L Clark, Peter K Kaiser
1Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Purpose:
To report a case of bilateral endogenous endophthalmitis caused by a HACEK group organism (Actinobacillus actinomycetemcomitans).
Methods:
An 85-year-old Caucasian female presented with bilateral light perception visual acuity, anterior chamber cells, hypopyon, posterior synechiae, and no red reflex.
Results:
The patient underwent bilateral vitrectomy, with topical, intravitreal, and systemic antibiotics. Vitreous cultures revealed gram-negative cocco bacilli consistent with Actinobacillus actinomycetemcomitans. At final follow-up, visual acuity was 20/25 RE and 20/40 LE.
Conclusions:
Prompt diagnosis and treatment of HACEK [Hemophilus sp. (parainfluenzae, aphrophilus, paraphrophilus), Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corodens, and Kingella kingae] group bacterial endophthalmitis can yield good results.
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