Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Specific tetraspanin functions.

M E Hemler1

  • 1Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA.

The Journal of Cell Biology
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Tetraspanins, abundant transmembrane proteins, are gaining attention. New genetic and biochemical data highlight their crucial roles in cellular functions and complexes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Renal disease appears not to affect carcinogenesis in CD151-null mice.

Oncogene·2013
Same author

Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.

Oncogene·2012
Same author

Retooling of the beta 4 integrin in tumor cells--ligands lost and kinase gained.

Developmental cell·2001
Same author

Beta1 integrins show specific association with CD98 protein in low density membranes.

BMC biochemistry·2001
Same author

EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily.

The Journal of biological chemistry·2001
Same author

Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific beta(1) integrins.

The Journal of biological chemistry·2001
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
Same journal

Meiotic CENP-C supports centromere assembly and kinetochore recruitment in spermatogenesis.

The Journal of cell biology·2026
Same journal

Phosphatidylserine and RhoB connect PI4P and PA metabolism to maintain plasma membrane identity.

The Journal of cell biology·2026
Same journal

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
See all related articles

Area of Science:

  • Molecular and Cellular Biology
  • Protein Biochemistry
  • Genetics

Background:

  • Tetraspanins are a large family of transmembrane proteins.
  • These proteins are abundantly expressed across various cell types.
  • Historically, tetraspanins have received limited research focus.

Purpose of the Study:

  • To highlight the growing importance of tetraspanins.
  • To underscore emerging genetic evidence related to tetraspanins.
  • To present new insights into tetraspanin biochemistry and function.

Main Methods:

  • Review of recent genetic studies.
  • Analysis of biochemical data on tetraspanin complexes.
  • Functional studies of tetraspanin-mediated processes.

Related Experiment Videos

Main Results:

  • Emerging genetic evidence strongly supports tetrasponin significance.
  • New biochemical data reveal complex interactions.
  • Functional studies demonstrate key roles in cellular processes.

Conclusions:

  • Tetraspanins are critical players in cell biology.
  • Further research into tetraspanin complexes is warranted.
  • Understanding tetraspanins is essential for advancing molecular and cellular science.