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D-amphetamine does not improve outcome of somatosensory training
1Department of Neurology, University of Münster, Germany. knecht@uni-muenster.de
Background:
D-amphetamine has been shown to affect early stages of stroke recovery, and may have a beneficial effect on functions when administered later after stroke.
Objective:
To test D-amphetamine effects on skill acquisition after the acute or subacute stages of stroke, when lesion-related structural changes have consolidated.
Methods:
Sixteen healthy subjects were treated with D-amphetamine during a 4-week training of tactile frequency discrimination in a placebo-controlled, double-blind design.
Results:
All subjects improved significantly in tactile temporal acuity. However, improvement did not differ in subjects treated with or without D-amphetamine.
Conclusion:
No beneficial effect of D-amphetamine on somatosensory training improvements was found in healthy subjects.