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Related Experiment Videos

Interaction between human polymorphonuclear leukocytes and Streptococcus milleri group bacteria.

Anna Wanahita1, Elizabeth A Goldsmith, Daniel M Musher

  • 1Medical Service, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA. wanahita@aol.com

The Journal of Infectious Diseases
|January 5, 2002
PubMed
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Streptococcus milleri group (SMG) bacteria can cause abscesses by resisting killing by human immune cells (polymorphonuclear leukocytes, PMNL). SMG also inhibits PMNL arrival, aiding bacterial proliferation and infection.

Area of Science:

  • Microbiology
  • Immunology
  • Pathogenesis

Background:

  • Streptococcus milleri group (SMG) bacteria, including S. constellatus, S. intermedius, and S. anginosus, are known for causing abscesses.
  • The interaction between SMG and human immune cells, specifically polymorphonuclear leukocytes (PMNL), is crucial for understanding their pathogenicity.

Purpose of the Study:

  • To investigate the interaction of SMG with human PMNL.
  • To elucidate the mechanisms by which SMG contribute to abscess formation.

Main Methods:

  • Incubation of SMG with pooled normal human serum and PMNL.
  • Assessment of PMNL chemotaxis, ingestion, and killing of SMG compared to Staphylococcus aureus and viridans streptococci.

Main Results:

Related Experiment Videos

  • SMG stimulated less PMNL chemotaxis compared to Staphylococcus aureus.
  • PMNL ingested higher numbers of SMG and viridans streptococci but exhibited slower and less effective killing.
  • Viridans streptococci shared some resistance properties with SMG despite rarely causing abscesses.

Conclusions:

  • Relative resistance to PMNL killing and inhibition of chemotaxis are key factors contributing to SMG's abscess-forming capacity.
  • Further research is needed to explain why viridans streptococci share these properties without frequently causing abscesses.