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Related Experiment Videos

Toxicological studies on cefuroxime sodium.

K Capel-Edwards, R M Atkinson, D A Pratt

    Toxicology
    |May 1, 1979
    PubMed
    Summary

    Cefuroxime sodium demonstrated low acute toxicity in mice and was well tolerated in multiple species across various administration routes. Long-term studies revealed no serious toxic effects, indicating a favorable safety profile for this antibiotic.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Antibiotic Research

    Background:

    • Cefuroxime sodium is a widely used cephalosporin antibiotic.
    • Understanding its toxicological profile is crucial for safe clinical application.

    Purpose of the Study:

    • To evaluate the acute and subchronic toxicity of cefuroxime sodium.
    • To assess the safety of cefuroxime sodium in various animal models, including reproductive toxicity.

    Main Methods:

    • Acute toxicity was determined by intravenous LD50 in mice and maximum tolerated doses in mice, rats, cats, dogs, and monkeys via different routes.
    • Subchronic toxicity was assessed in rats, dogs, and monkeys through subcutaneous, intramuscular, and intravenous administration for durations of 1 to 6 months.
    • Reproductive toxicity studies were conducted in mice and rabbits.

    Main Results:

    • The intravenous LD50 in mice was 10.4 g/kg. High doses were generally well tolerated across species and routes.
    • No serious toxic effects were observed in subchronic studies. Minor hematological changes were linked to injection site reactions.
    • No adverse effects on fertility, organogenesis, or offspring development were noted in reproductive studies.

    Conclusions:

    • Cefuroxime sodium exhibits a low toxicity profile.
    • The antibiotic is well-tolerated in animal models, supporting its safety in therapeutic use.
    • Reproductive studies indicate no adverse effects, further supporting the safety of cefuroxime sodium.

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