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Related Experiment Videos

The malaria-infected red blood cell: structural and functional changes.

B M Cooke1, N Mohandas, R L Coppel

  • 1Department of Microbiology, P.O. Box 53, Monash University, Victoria 3800, Australia.

Advances in Parasitology
|January 5, 2002
PubMed
Summary

Malaria parasites (Plasmodium) alter red blood cells, changing their structure and function. Understanding these changes offers new ways to reduce virulence and develop antimalarial drugs.

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Area of Science:

  • Cell Biology
  • Parasitology
  • Hematology

Background:

  • Malaria parasites, genus Plasmodium, infect red blood cells.
  • Infection induces significant changes in red blood cell structure and function.

Purpose of the Study:

  • To elucidate structural and functional alterations in red blood cells caused by Plasmodium invasion and maturation.
  • To explore potential therapeutic targets for reducing parasite virulence and developing novel antimalarials.

Main Methods:

  • Analysis of red blood cell morphology and rheological properties post-infection.
  • Investigation of changes in red blood cell membrane skeleton and cytoplasmic structures.

Main Results:

  • Parasite invasion leads to altered red blood cell morphology, increased membrane rigidity, reduced deformability, and enhanced adhesiveness.

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  • New structures appear in the red blood cell cytoplasm, and new proteins are found at the membrane skeleton.

    • Conclusions:

    • Understanding parasite-induced red blood cell modifications enhances knowledge of normal red blood cell structure-function relationships.
    • Interference with these host-parasite interactions presents novel strategies for antimalarial drug development.