[Dose distribution of bone-seeking radiopharmaceuticals in the rat (author's transl)]

The biokinetics of 32P-P, 32P-PPi, 85Sr, 99mTc- and 113Sn-EHDP were evaluated in the young rat. The dose distribution of the beta-emitters 32P, 89Sr, 121Sn and 188Re was calculated from the measured biological half-lifes. The highest dose to soft tissues and therefore also to bone-marrow in relation to the bone dosis was found for 32P-P. The lowest dose was found for 89Sr. Favourable results were obtained in the diphosphonate compounds. The use of 32P-PPi instead of 32P-P appears to be advantageous, too. The dose relation between normal bone and the growth plate of the femur was significantly lower for 89Sr than for the other radiopharmaceuticals.