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Glutamate in the enteric nervous system.

A L Kirchgessner¹

¹Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA. akirchgessner@netmail.hscbklyn.edu

Current Opinion in Pharmacology

|January 5, 2002

Summary

Glutamate influences gut motility, but its receptors remain unclear. Recent studies reveal functional group I metabotropic glutamate receptors in the enteric nervous system, offering new drug targets for gut function.

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Area of Science:

Gastroenterology and Neuroscience
Neuropharmacology of the Enteric Nervous System

Background:

Glutamate is implicated in regulating gastrointestinal motility and secretion.
The specific receptor subtypes mediating glutamate's effects in the gut are not fully elucidated.

Purpose of the Study:

To investigate the role of glutamate receptor subtypes in the enteric nervous system.
To explore potential new therapeutic targets for modulating gut function.

Main Methods:

Pharmacological characterization of enteric glutamate receptor subtypes.
Investigation of functional group I metabotropic glutamate receptors in the enteric nervous system.

Main Results:

Evidence suggests the presence of functional group I metabotropic glutamate receptors in the enteric nervous system.
These receptors appear to play a role in enteric reflexes.

Conclusions:

The discovery of functional group I metabotropic glutamate receptors in the enteric nervous system expands our understanding of glutamate's role in gut function.
These findings present novel targets for pharmacological intervention in gastrointestinal disorders.

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