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Control of growth and development of the feto-placental unit
1CIHR Group in Fetal and Neonatal Health and Development, Lawson Health Research Institute and Child Health Research Institute, University of Western Ontario, London, Canada. vhan@uwo.ca
Current Opinion in Pharmacology
|January 5, 2002
Abstract:
Classical gene targeting has identified many genes important for fetal and placental development. Null mutation of these genes may lead to fetal growth restriction, malformation or embryonic death. Growth restriction of epigenetic basis can predispose to adult-onset diseases. The mechanisms underlying this process, termed 'fetal programming', are beginning to be understood.