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Non-polio enteroviruses in acute flaccid paralysis
A Kapoor1, A Ayyagari, T N Dhole
1Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Indian Journal of Pediatrics
|January 5, 2002
Summary
Non-polio enteroviruses (NPEV) were identified in children with acute flaccid paralysis (AFP). This research helps understand circulating NPEV serotypes, aiding diagnosis and treatment for neonatal infections.
Area of Science:
- Virology
- Pediatrics
- Epidemiology
Background:
- Human enteroviruses are a primary cause of aseptic meningitis and neonatal sepsis.
- Infections in neonates can be life-threatening, necessitating effective diagnostic and therapeutic strategies.
Purpose of the Study:
- To identify frequent non-polio enterovirus (NPEV) serotypes in children with acute flaccid paralysis (AFP).
- To provide data for future research on NPEV serotypes in circulation.
- To inform diagnostic and therapeutic approaches for enteroviral infections.
Main Methods:
- Stool samples were collected from 523 children under 4 years old with AFP symptoms in Uttar Pradesh and Bihar, India.
- Non-polio enteroviruses (NPEV) were isolated using cell culture-based neutralization assays.
- Enterovirus serotypes from isolated NPEV were identified.
Main Results:
- Non-polio enteroviruses (NPEV) were detected in 191 out of 523 children with acute flaccid paralysis (AFP).
- The study identified specific NPEV serotypes circulating in the studied population.
- Data generated will support future investigations into NPEV epidemiology.
Conclusions:
- Understanding prevalent NPEV serotypes can guide the development of rapid and cost-effective diagnostic tools.
- This knowledge may help in reserving high-titer immune globulin for neonatal intravenous therapy.
- Findings could potentially reduce unnecessary hospitalizations by enabling targeted interventions.