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[Telomerase activity in stool of patients with colorectal cancer]
1Department of General Surgery, Beijing Military Area General Hospital, Beijing 100700, China.
Objective:
To probe into the method for screening colorectal cancer by the way of stool.
Methods:
Telomerase activity in the stool of patients with colorectal cancer was determined by PCR-TRAP.
Results:
The positive rate of telomerase activity in the stool of patients with colorectal cancer was 62.8%. Its sensitivity, specificity and positive predictive value were 62.8%, 95.7%, and 96.4%, respectively. Telomerase activity in stool was not obviously correlated with Duke's stage, lymphatic metastasis and tumor location. Telomerase activity was also found in the stool sample of a patient with colonic adenoma.
Conclusion:
The determination of telomerase activity in the stool of patients with colorectal cancer contributes to the improvement of screening and diagnosis of colorectal cancer.