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[Histopathology and immunohistochemical expression of precursor lesions of cervical adenocarcinoma]
1Department of Pathology, Beijing Obstetrics and Gynecology Hospital, Beijing 100006, China.
Objective:
To discuss the histopathology and immunohistochemical expression in precursor lesion of cervical adenocarcinoma-cervical intraepithelial glandular neoplasia (CIGN).
Methods:
Histopathological examination and immunohistochemical study (SP method) were performed on 101 cases of CIGN.
Results:
Criteria for histological grading of CIGN into three degrees, grade I to III, were proposed according to the hyperchromasia and the stratification of nuclei, number of mitoses and the amount of intracellular mucin. Adenocarcinoma in situ was classified as CIGN-III. 46.53% (47/101) CIGN showed a co-existence of CIN (SIL). 45 cases were CEA positive (44.55%) and 38 showed apical and luminal positivity. The positive rate of PCNA was 63.54% and was 100% in CIGN-III. The positive rate of ER was 81.48% (66/81). The expression of ER was often decreased or missing in certain cases. The positive rate of HPV 6/11 in CIGN I-III was 34.09% (30/88), 31.82% (28/88), and 3.41% (3/88), respectively.
Conclusions:
Histological grading of CIGN is important. Immunohistochemical staining for CEA, PCNA and ER may be helpful in diagnosis and differential diagnosis of CIGN.
