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Updated: Oct 3, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
[Study on the mechanism of thrombosis by lupus anticoagulant inhibited protein C pathway]
Objective:
To study the mechanism of thrombosis in systemic lupus erythematosus (SLE) patients with protein C (PC) pathway inhibition by lupus anticoagulant(LA).
Methods:
Phosphoethylamine(PE) dependent activated protein C (APC) inhibiting assay (modifed DRVVT) was used to observe the inhibition of APC activity after incubation of IgG from both normal and SLE patients with PE.
Results:
The activity of anticoagulation of APC was augmented by PE. Proportionally to its concentration, LA could inhibit the PE dependent anticoagulation of APC. The inhibition of LA-IgG on APC in the LA positive SLE patients with thrombosis was stronger than that in LA negative non-thrombosis patients; but IgG has no effect on the APC activity in normal person.
Conclusion:
LA inhibiting the PC pathway by interfering with PE may be the important reason of thrombosis in SLE patients.
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