Jove
Visualize
Contact Us

Related Experiment Videos

Future perspectives.

N Hastie1

  • 1MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, U.K. n.hastie@hgu.mrc.ac.uk

Essays in Biochemistry
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Transcription and RNA-binding proteins play crucial roles in development and disease. New high-throughput methods and bioinformatics are essential for understanding their complex functions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Actin: a novel interaction partner of WT1 influencing its cell dynamic properties.

Oncogene·2009
Same author

hnRNP-U directly interacts with WT1 and modulates WT1 transcriptional activation.

Oncogene·2006
Same author

Multiple roles for the Wilms' tumor suppressor, WT1.

Cancer research·1999
Same author

Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13.

Proceedings of the National Academy of Sciences of the United States of America·1998
Same author

Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia.

Proceedings of the National Academy of Sciences of the United States of America·1998
Same author

Multiple roles for the Wilms' tumour suppressor gene, WT1 in genitourinary development.

Molecular and cellular endocrinology·1998
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Transcription is intrinsically linked with post-transcriptional RNA processing.
  • Transcription factors are vital in development and disease, as evidenced by genetic studies.
  • Genome projects are revealing numerous novel transcription factors and RNA-binding proteins.

Purpose of the Study:

  • To highlight the multifaceted roles of proteins, including transcription factors and RNA-binding proteins.
  • To emphasize the need for advanced methodologies in managing and interpreting large biological datasets.

Main Methods:

  • Genetic analysis in model organisms (flies) and humans.
  • Bioinformatic approaches for analyzing large-scale genomic data.
  • High-throughput screening techniques.

Related Experiment Videos

Main Results:

  • Identification of numerous novel transcription factors and RNA-binding proteins.
  • Evidence for proteins possessing dual roles at transcriptional and post-transcriptional levels.
  • Demonstration of the coupling between transcription and splicing.

Conclusions:

  • Proteins can exhibit diverse functions across different biological processes.
  • The complexity of genomic information necessitates innovative high-throughput and bioinformatic strategies.
  • Understanding transcription factor and RNA-binding protein roles is key to developmental biology and disease research.