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Antibacterial agents that inhibit histidine protein kinase YycG of Bacillus subtilis
K Yamamoto1, T Kitayama, S Minagawa
1Department of Agricultural Chemistry, Kinki University, Nara, Japan.
Bioscience, Biotechnology, and Biochemistry
|January 5, 2002
Abstract:
We demonstrated in vitro that YycG-YycF of Bacillus subtilis constitutes a two-component system and shows a specificity of the sensor protein for the cognate phosphorylation partner. Based on inhibition of such an autophosphorylation of YycG, we searched imidazole and zerumbone derivatives to identify the antibacterial agents such as NH125, NH126, NH127, and NH0891.