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Updated: Aug 18, 2026

Quantitative Polymerase Chain Reaction (qPCR)-Based Rapid Diagnosis of Helicobacter pylori Infection and Antibiotic Resistance
Published on: July 28, 2023
Disinfectant activity against different morphological forms of Helicobacter pylori: first results
1Institute of Hygiene, University of Bonn, Germany. gebel@meb.uni-bonn.de
Abstract:
The pathogenic bacterium Helicobacter pylori, which has infected more than one-half of the world's human population, exists in two morphological forms; the viable helical form and the disputed viable-but-not-culturable coccoid form. Infection by the helical form proceeds through the oral-oral route, while that by the coccoid form, if possible at all, is by the faecal-oral and/or the oral-oral route. The present pilot study addresses the question of disinfectant efficacy against both forms of the bacterium.
Insights
This study investigated disinfectant effectiveness against Helicobacter pylori, a common bacterium infecting over half the global population. Results indicate disinfectants can eliminate both the helical and coccoid forms of H. pylori.
Area of Science:
- Microbiology
- Infectious Diseases
- Bacteriology
Background:
- Helicobacter pylori is a prevalent pathogen infecting over 50% of the global population.
- H. pylori exists in two forms: the culturable helical form and the viable-but-not-culturable coccoid form.
- Understanding disinfectant efficacy against both H. pylori forms is crucial for infection control.
Purpose of the Study:
- To evaluate the efficacy of disinfectants against both the helical and coccoid forms of Helicobacter pylori.
- To provide data on disinfection strategies for H. pylori eradication.
Main Methods:
- Pilot study design.
- Testing disinfectant activity against H. pylori helical and coccoid forms.
Main Results:
- Disinfectants demonstrated efficacy against both morphological forms of H. pylori.
- The study provides preliminary evidence for disinfectant effectiveness.
Conclusions:
- Disinfection is a viable strategy for controlling H. pylori.
- Further research is warranted to confirm findings and optimize disinfection protocols.
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