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[Chrysiasis].

K Loddenkemper1, F Buttgereit

  • 1Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie Universitätsklinikum Charité der Humboldt-Universität zu Berlin Schumannstrasse 20-21 10117 Berlin, Germany.

Zeitschrift Fur Rheumatologie
|January 5, 2002
PubMed
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Chrysiasis is a rare skin pigmentation caused by gold treatments for rheumatoid arthritis. This case highlights the condition

Area of Science:

  • Rheumatology
  • Dermatology
  • Toxicology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • Parenteral gold compounds were historically used for RA treatment.
  • Chrysiasis is a known but uncommon adverse effect of gold therapy.

Observation:

  • A 78-year-old woman with RA presented after 3 years of parenteral gold administration.
  • The patient exhibited signs of chrysiasis, a permanent skin pigmentation.
  • The exact cause of gold-induced skin pigmentation remains multifactorial.

Findings:

  • Case report detailing chrysiasis in a patient undergoing gold therapy for RA.
  • Documentation of a rare, permanent skin discoloration linked to gold administration.
  • Highlights the persistent nature of chrysiasis.

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Implications:

  • Understanding the long-term side effects of gold therapy.
  • Importance of monitoring for dermatological adverse events in patients receiving gold.
  • Further research needed to elucidate the mechanisms of chrysiasis development.