[Hormonal replacement therapy and inflammatory response--update]
Related Experiment Video
Updated: Oct 3, 2026

Intravenous Endotoxin Challenge in Healthy Humans: An Experimental Platform to Investigate and Modulate Systemic Inflammation
Published on: May 16, 2016
D Zeltser1, S Berliner, I Shapira
1Department of Medicine D, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv.
Abstract:
Recent studies have shown that the administration of hormonal replacement therapy (HRT) to postmenopausal women might be associated with the appearance of increased concentrations of C-reactive protein (CRP). This marker of inflammation might be associated with an unfavorable outcome regarding the appearance of ischemic vascular diseases and accelerated atherosclerosis in elderly women. In addition, the use of HRT might be associated with an enhanced thrombotic tendency. Therefore, the administration of HRT to individuals who have increased concentrations of inflammatory markers (CRP for example) and/or thrombophilic ones, might be associated with an eventual less favorable clinical outcome.
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