[Comparison of flow-volume curve parameters in patients with respiratory sarcoidosis and chronic non-specific...

62 patients with respiratory sarcoidosis (RS) and 50 patients with chronic nonspecific pulmonary diseases (CNSPD) inhaled 1 ml (250 mg ipratronium bromide and 500 mcg phenoterol hydrobromide) berodual by means of nebulizer. 68% of the examinees responded with obstruction of the distal part of the respiratory tree. RS causes partially reversible defects in permeability, primarily at the level of small bronchi. Berodual-induced changes in the curve flow-volume in RS differed from those in CNSPD patients by the absence of a rise in the exhalation power. Lofgren's syndrome deteriorated reversibility of bronchial permeability defects in RS patients. Smoking effects on bronchial permeability and reversibility of relevant defects in RS patients were insignificant. Pathogenesis of reversible obstruction in sarcoidosis demands further studies.