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Related Experiment Video

Updated: Jun 28, 2026

Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK

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Published on: December 18, 2012

HLA-B51 and its allelic types in association with Behçet's disease and recurrent aphthous stomatitis in Korea.

H K Chang¹, J U Kim, K S Cheon

¹Department of Internal Medicine, Asan Kangnung Hospital, Ulsan University, Kangnung. hanks@knh.co.kr

Clinical and Experimental Rheumatology

|January 5, 2002

Summary

The HLA-B51 antigen is significantly more prevalent in Korean Behçet

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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

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Published on: March 1, 2024

Area of Science:

Immunogenetics
Rheumatology
Ophthalmology

Background:

Behçet's disease (BD) is a multisystem inflammatory disorder.
Recurrent aphthous stomatitis (RAS) shares some clinical features with BD.
The role of Human Leukocyte Antigen (HLA) B51 in BD pathogenesis is under investigation.

Purpose of the Study:

To evaluate the association of HLA-B51 antigen and its allelic types with Behçet's disease (BD) and recurrent aphthous stomatitis (RAS).
To investigate the correlation of HLA-B51 with diagnostic types and clinical variables of BD.

Main Methods:

DNA typing of HLA-B51 using nested PCR-SSP in 61 BD patients, 56 RAS patients, and 70 healthy controls.
Quality control using microlymphocytotoxicity assay.
Direct DNA sequencing for allelic type analysis.

Main Results:

HLA-B51 prevalence was 55.7% in BD patients, 16.1% in RAS patients, and 15.7% in controls.
Complete BD patients (100%) and those with uveitis (p=0.003) or erythema nodosum (p=0.042) showed higher HLA-B51 prevalence.
The major allelic type in all groups was HLA-B*51011.

Conclusions:

HLA-B51 is significantly more prevalent in Korean BD patients compared to RAS patients and healthy controls.
HLA-B51 is associated with severe clinical manifestations of BD, including uveitis, erythema nodosum, and complete BD.
HLA-B51 serves as a genetic marker for severe Behçet's disease.