Related Experiment Videos
[Disseminated intravascular coagulation(DIC)]
1Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Orvostudományi Kar II. Belgyógyászati Klinika.
Insights
Disseminated intravascular coagulation (DIC) presents diverse clinical outcomes, including thrombosis or bleeding. Understanding its pathogenesis, particularly sepsis-associated DIC, improves diagnosis and treatment.
Area of Science:
- Hematology
- Pathophysiology
- Critical Care Medicine
Context:
- Disseminated intravascular coagulation (DIC) is a complex syndrome with varied clinical manifestations.
- DIC can manifest as venous thromboembolism, severe bleeding, or organ failure.
- Understanding the underlying pathogenetic events is crucial for effective management.
Purpose:
- To review the multifaceted nature of DIC, emphasizing the link between sepsis and DIC.
- To highlight advancements in laboratory diagnosis of DIC.
- To discuss emerging therapeutic strategies for DIC, particularly sepsis-induced DIC.
Summary:
- DIC encompasses diverse clinical presentations, including thrombotic and hemorrhagic complications, driven by various underlying etiologies.
- The review focuses on sepsis-associated DIC, detailing its pathogenesis, diagnostic approaches, and novel therapeutic interventions.
- Emphasis is placed on the critical link between sepsis and DIC, improving clinical interpretation and management.
Impact:
- Enhanced understanding of DIC's diverse presentations and pathogenetic mechanisms.
- Improved diagnostic accuracy for sepsis-associated DIC.
- Guidance on new therapeutic avenues for managing DIC, potentially improving patient outcomes.
Abstract:
Disseminated intravascular coagulation (DIC) remains a multifaced syndrome, which may develop with different background and aetiology into venous thromboembolism (mainly chronic, paraneoplastic DIC) or into severe bleeding, factor consumption, thrombocytopenia (i.e. gynaecological acute DIC) or may appear as microthrombotic organ hypoperfusion, organ-failure and necrosis (septic DIC variant). The understanding and consideration of pathogenetic events promotes better identification and interpretation of DIC syndrome and its categories, render more adequate diagnostics and therapy available. The vast majority of new data accumulated in the septic type of DIC, and this general review also tries to put the major emphasis on sepsis-DIC link, laboratory diagnosis and apparent new therapeutic approaches.