[Disseminated intravascular coagulation(DIC)]

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Updated: Oct 3, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

M Udvardy1

  • 1Debreceni Egyetem, Orvos- és Egészségtudományi Centrum, Orvostudományi Kar II. Belgyógyászati Klinika.

Orvosi Hetilap
|January 5, 2002
PubMed

Insights

Disseminated intravascular coagulation (DIC) presents diverse clinical outcomes, including thrombosis or bleeding. Understanding its pathogenesis, particularly sepsis-associated DIC, improves diagnosis and treatment.

Area of Science:

  • Hematology
  • Pathophysiology
  • Critical Care Medicine

Context:

  • Disseminated intravascular coagulation (DIC) is a complex syndrome with varied clinical manifestations.
  • DIC can manifest as venous thromboembolism, severe bleeding, or organ failure.
  • Understanding the underlying pathogenetic events is crucial for effective management.

Purpose:

  • To review the multifaceted nature of DIC, emphasizing the link between sepsis and DIC.
  • To highlight advancements in laboratory diagnosis of DIC.
  • To discuss emerging therapeutic strategies for DIC, particularly sepsis-induced DIC.

Summary:

  • DIC encompasses diverse clinical presentations, including thrombotic and hemorrhagic complications, driven by various underlying etiologies.
  • The review focuses on sepsis-associated DIC, detailing its pathogenesis, diagnostic approaches, and novel therapeutic interventions.
  • Emphasis is placed on the critical link between sepsis and DIC, improving clinical interpretation and management.

Impact:

  • Enhanced understanding of DIC's diverse presentations and pathogenetic mechanisms.
  • Improved diagnostic accuracy for sepsis-associated DIC.
  • Guidance on new therapeutic avenues for managing DIC, potentially improving patient outcomes.

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