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Proximal gastric motor and sensory function in slow transit constipation
C Penning1, M K Vu, J B Delemarre
1Dept. of Gastroenterology-Hepatology, Leiden University Medical Center, The Netherlands.
Scandinavian Journal of Gastroenterology
|January 5, 2002
Summary
Slow transit constipation is linked to impaired gastric motility. Reduced proximal gastric compliance and fundus relaxation in patients suggest a generalized gastrointestinal disorder.
Area of Science:
- Gastroenterology
- Gastrointestinal Motility Disorders
- Physiology
Background:
- Slow transit constipation (STC) may represent a broader gastrointestinal motility dysfunction.
- Understanding the gastric contribution to STC is crucial for comprehensive patient care.
Purpose of the Study:
- To investigate gastric motor and sensory functions in patients with STC.
- To explore the relationship between gastric function, symptoms, and hormone levels in STC.
Main Methods:
- Barostat-based evaluation of gastric motor and sensory function in 17 STC patients and 16 controls.
- Assessment included isobaric distension, liquid meal tolerance, symptom scoring (visual analog scales), and postprandial gastrointestinal hormone analysis.
Main Results:
- Patients with STC exhibited significantly reduced proximal gastric compliance.
- Impaired postprandial fundus relaxation was observed in STC patients, correlating with upper gastrointestinal symptoms.
- Reduced postprandial secretion of cholecystokinin and gastrin was noted in STC patients.
Conclusions:
- STC is associated with reduced proximal gastric compliance and impaired postprandial fundus relaxation.
- These findings support the hypothesis that STC is part of a pan-enteric (widespread) gastrointestinal motility disorder.