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Modified synthesis of 11-[14C]-clozapine
H Matloubi1, M Ghandi, M R Zarrindast
1Nuclear Research Center/AEOI, Chemical Division, Tehran, Iran. hmatloubi@seai.neda.net.ir
Abstract:
The reported synthetic pathway of 8-chloro-11-(4-methyl-1-piperazinyl)-11-[14C]-5H-dibenzo[b,e][1,4]diazapine (clozapine) was modified in several steps. The synthetic pathway was shortened by 60% and the total yield was increased from 6% to 23%.