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Spinocerebellar ataxia type 2 presenting as familial levodopa-responsive parkinsonism
1Neurological Institute, Taipei Veterans General Hospital, Taiwan, ROC. deshan@vghtpe.gov.tw
Annals of Neurology
|January 5, 2002
Abstract:
A genetic analysis identified 2 patients, approximately one-tenth of our patients with familial parkinsonism, who had expanded trinucleotide repeats in SCA2 genes. The reduction of 18F-dopa distribution in both the putamen and caudate nuclei confirmed that the nigrostriatal dopaminergic system was involved in parkinsonian patients with SCA2 mutation.