[Effect of organic solvents on hearing organ]
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Updated: Oct 3, 2026

The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
1Katedry Profilaktyki Zdrowotnej Akademii Medycznej, Poznaniu.
Abstract:
This paper reviews the studies of ototoxicity of organic solvents. Experimental and clinical studies show some harmful effects exerted on hearing organ by organic solvents, especially by toluene, xylene, styrene, carbon disulfide, n-hexane and trichloroethylene. These chemicals may affect different levels of auditory pathways. When assessing these effects in industrial conditions, it is necessary to consider the noise activity and interactions between organic solvents and noise. Further research should focus particularly on one major question on whether workplace conditions free from exceeding hygiene standards of organic solvents are completely safe for workers.
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