Structure of the mouse calcitonin/calcitonin gene-related peptide alpha and beta genes
P M Thomas1, I Nasonkin, H Zhang
1Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
We report the cloning, genomic organization and sequence of the mouse alpha-CALC and beta-CALC genes. The two genes share extensive sequence homology. The transcription units of both genes contain 6 exons. Transcripts of the alpha-CALC gene were found to alternatively include exon 4 or exons 5 and 6. For the beta-CALC gene exon 4 was not detected in transcripts derived from this gene. The predicted mouse alpha-CGRP was found to be identical to rat alpha-CGRP, however, beta-CGRP predicted amino acid sequences revealed three amino acid differences suggesting these residues are not critical to CGRP function.
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