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Plaque-like structures and arteriosclerotic changes in "diffuse neurofibrillary tangles with calcification" (DNTC).

S Terada1, H Ishizu, Y Tanabe

  • 1Department of Neuropsychiatry, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. terada_1@cc.okayama-u.ac.jp

Acta Neuropathologica
|January 5, 2002
PubMed
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Diffuse neurofibrillary tangles with calcification (DNTC) is a rare dementia. Researchers discovered novel plaque-like structures (PLS) and significant arteriosclerosis in DNTC patients, distinct from Alzheimer's disease.

Area of Science:

  • Neuropathology
  • Neurodegenerative Diseases
  • Vascular Dementia

Background:

  • Diffuse neurofibrillary tangles with calcification (DNTC) is a rare dementia.
  • It presents with fronto-temporal atrophy, neuronal loss, astrocytosis, neurofibrillary tangles, and Fahr-type calcification, notably lacking senile plaques.

Purpose of the Study:

  • To identify novel histopathological abnormalities in DNTC.
  • To investigate the presence and characteristics of plaque-like structures (PLS) in DNTC.
  • To evaluate arteriosclerosis and white matter lesions in DNTC patients.

Main Methods:

  • Histopathological examination of brain tissue from DNTC patients.
  • Detection and characterization of "plaque-like structures" (PLS) using various stains (e.g., methenamine silver).

Related Experiment Videos

  • Assessment of medullary artery sclerosis and white matter lesions, compared to age-matched controls.

    • Main Results:

    • A novel abnormality, "plaque-like structures" (PLS), was identified in DNTC patients.
    • PLS are oval, eosinophilic masses associated with small vessels and astrocytes, composed of unique fiber types not seen in Alzheimer's disease.
    • Significant medullary artery sclerosis and white matter lesions were observed in DNTC patients, independent of hypertension or beta-amyloid.

    Conclusions:

    • Plaque-like structures (PLS) represent a unique histopathological feature of diffuse neurofibrillary tangles with calcification (DNTC).
    • Arteriosclerosis and white matter lesions are prominent features in DNTC, contributing to the disease pathology.
    • DNTC pathology is distinct from Alzheimer's disease, highlighting its unique characteristics.