[Changes of serum il-6 and CRP after chemotherapy in patients with ovarian carcinoma]

The levels of IL-6, CRP and TPS were measured in 38 patients with ovarian carcinoma in different histological types and clinical stages. The values IL-6, CRP and TPS were determined before and after chemotherapy. Pretreatment levels of IL-6, CRP and TPS were significantly increased in carcinoma patients relatively to the control group. The frequency of increased results and absolute value of IL-6 and TPS levels showed tendency to significant increase with the stage of disease. The highest values of IL-6 were observed in patients with serous and mucous carcinoma. The levels of IL-6, CRP and TPS were decreased above cut off values in patients with remission, and did not changed in patients with progression and stabilization disease. The results suggest that IL-6 especially in the combination with CRP and TPS may be useful in the diagnosis and the evaluation of therapy of patients with ovarian carcinoma.