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[Drug-induced heart failure].

M Negrusz-Kawecka1

  • 1Katedra i Klinika Kardiologii AM we Wrocławiu.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|January 5, 2002
PubMed
Summary

Certain medications can induce heart failure, even in individuals without prior heart conditions. This review examines drugs like cytostatics, NSAIDs, and antidepressants that may cause or worsen heart failure.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Internal Medicine

Context:

  • Heart failure is a significant clinical syndrome often linked to cardiovascular diseases.
  • Drug-induced heart failure is an emerging concern, affecting patients with and without pre-existing conditions.
  • Understanding drug mechanisms is crucial for managing cardiovascular health.

Purpose:

  • To review the potential of various drug classes to induce or exacerbate heart failure.
  • To explore the pathophysiological mechanisms by which drugs can cause adverse cardiac events.
  • To provide a comprehensive overview of drug-induced cardiotoxicity.

Summary:

  • Several drug categories, including cytostatics, immunomodulators, NSAIDs, calcium channel blockers, beta-blockers, antiarrhythmics, anesthetics, and antidepressants, are reviewed for their potential to cause heart failure.
  • Drugs increasing preload, afterload, or possessing negative inotropic properties are implicated.
  • This review highlights the risk of drug-induced heart failure in susceptible patients.

Impact:

  • Informing clinicians about potential drug-induced cardiotoxicity to improve patient safety.
  • Guiding therapeutic choices and monitoring strategies for patients at risk of heart failure.
  • Contributing to the understanding of iatrogenic causes of heart failure.

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