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Sequence analysis of the rat phenylalanine hydroxylase gene promoter
D Rees1, M J Fisher, I L McDowall
1Department of Biological Sciences, Chester College of Higher Education, Chester, CH1 4BJ, UK.
DNA Sequence : the Journal of DNA Sequencing and Mapping
|January 5, 2002
Abstract:
We have characterized the 5'-end (3218 bp) of the rat phenylalanine hydroxylase (PAH) gene. Within this PAH promoter sequence, we have identified a number of putative regulatory sites analogous to those present in the human and murine PAH promoters. In particular, potential HNF 1 binding sites and a CRE have been identified. These sequences respectively bind HNF1 and CREB transcription factors present in rat nuclear extracts and may be significant in the tissue-specific and hormonal control of PAH expression.