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Related Experiment Videos

How do the atypical antipsychotics work?

J Ananth1, K S Burgoyne, R Gadasalli

  • 1Department of Psychiatry, University of California Los Angeles, Harbor-UCLA-Medical Center, 1000 West Carson St., Bldg. F-9, Torrance, CA 90509-2910, USA. jananth@rei.edu

Journal of Psychiatry & Neuroscience : JPN
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

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Atypical antipsychotics target the limbic system in animal models. Their action in the nucleus accumbens improves positive symptoms, while prefrontal cortex action correlates with negative symptom improvement in schizophrenia.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Schizophrenia pathophysiology research benefits from understanding atypical antipsychotic mechanisms.
  • Atypical antipsychotics show preferential action in the limbic dopaminergic system in animal models.
  • Investigating drug effects on the c-fos gene, indicated by Fos protein levels, reveals regionally specific actions.

Purpose of the Study:

  • To explore the regional brain action of atypical antipsychotics.
  • To correlate specific brain region Fos protein increases with symptom improvement.
  • To investigate the relationship between atypicality and D2 dopamine receptor blockade.

Main Methods:

  • Utilizing animal models to study drug actions.
  • Measuring Fos protein levels in specific brain regions as a marker for gene activity.

Related Experiment Videos

  • Analyzing Fos increases in the nucleus accumbens, prefrontal cortex, and striatonigral pathway.

    • Main Results:

    • Atypical and typical antipsychotics increase Fos in the nucleus accumbens, linked to positive symptom improvement.
    • Atypical antipsychotics uniquely increase Fos in the prefrontal cortex, correlating with negative symptom improvement.
    • Fos increases in the striatonigral pathway are associated with extrapyramidal side effects of typical antipsychotics.

    Conclusions:

    • Regional Fos increases indicate the site, but not the mode, of antipsychotic action.
    • Atypical antipsychotic action is further defined by surmountable D2 dopamine receptor blockade.
    • Understanding these mechanisms aids in developing more effective antipsychotics with fewer side effects.